Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
نویسندگان
چکیده
Department of Pharmacology, University of Arizona Medical Center, Tucson, Arizona 85724 fD. H. R.]; Division of Radiobiology and Biophysics, University of Virginia School of Medicine, CharlottesvÃ1⁄4le,Virginia 22901 ¡W.B. L., C. J. K., H, A. H.]; Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland 21211 [L. J. M., S. M. L.J; and Biochemistry Cancer Research, Howard University Washington D C. 20001 [H. P.M.I.
منابع مشابه
Polyamine Depletion of Tumor Tissue and Subsequent Elevation of Spermidine in the Sera of Rats with 3924A Hepatomas after 5-Fluorouracil Administration1
Department of Pharmacology, University of Arizona Medical Center, Tucson, Arizona 85724 fD. H. R.]; Division of Radiobiology and Biophysics, University of Virginia School of Medicine, CharlottesvÃ1⁄4le,Virginia 22901 ¡W.B. L., C. J. K., H, A. H.]; Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland 21211 [L. J. M., S. M. L.J; and Biochemistry Cancer Research, Howar...
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Local irradiation of tumors of rats bearing 3924A hepatomas resulted in more than a doubling of the putrescine levvel and nearly a doubling of spermidine concentration in the serum within 12 hr. Within 24 hr, the putrescine concentration had increased four-fold in the serum, along with a continued increase in the spermidine concentration. The decrease in the spermidine concentration of the tumo...
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The concentrations of putrescine, spermidine, and spermine in liver of rats fed on 4-dimethylaminoazobenzene and in the resultant hepatomas were found to be significantly higher than were those observed in normal liver from rats of the same strain, sex, and age. These modifications were due to the carcinogen and not to the special low-riboflavin diet used to obtain the carcinogenic effect of 4-...
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1. The content of decarboxylated S-adenosylmethionine (AdoMet) in transformed mouse fibroblasts (SV-3T3 cells) was increased 500-fold to about 0.4fmol/cell when ornithine decarboxylase was inhibited by alpha-difluoromethylornithine. This increase was due to the absence of putrescine and spermidine, which serve as substrates for aminopropyltransferases with decarboxylated AdoMet as an aminopropy...
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ورودعنوان ژورنال:
- Cancer research
دوره 34 9 شماره
صفحات -
تاریخ انتشار 1974